New Artificial Enzyme Will Fight Parkinson's Disease

New Artificial Enzyme Will Fight Parkinson's Disease
New Artificial Enzyme Will Fight Parkinson's Disease

Video: New Artificial Enzyme Will Fight Parkinson's Disease

Video: Scientifically Speaking - S2L4 Artificial Enzymes: Making Molecules with a Purpose | Prof. G.Mugesh 2022, November
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Recently, scientists at Johns Hopkins Medical University have created an artificial enzyme that can stop the spread of misfolded alpha-synucleins. The development could form the basis of new treatments for Parkinson's disease. Artificial enzymes made from combinations of platinum and copper (these combinations are called bimetallic nanoalloys) are nano-sized and have strong antioxidant properties.

It is for these antioxidant properties that an artificial enzyme was created. The fact is that oxidative stress in the human body increases with age. This occurs under the influence of such age-related biological processes as protein degradation. Oxidative stress promotes the proliferation of misfolded alpha-synucleins, which are at the origin of Parkinson's disease.

Once injected into the brain, artificial enzymes find reactive oxygen species that cause oxidative stress and prevent them from harming neurons. In their action, artificial nanoenzymes are similar to catalase and superoxide dismutase - natural enzymes in our body that resist reactive oxygen species. The introduction of artificial nanoenzymes will enhance this positive effect.

The scientists summed up their study with the conclusions that the artificial enzymes they developed reduce the amount of reactive oxygen species, and also reduce the intensity of pathologies associated with alpha-synuclein.

image: M.E. Newman, Johns Hopkins Medicine

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