A team of scientists from Columbia University Medical Center and the University of North Carolina have developed a weight loss nanoplast. The results of the study in mice were published in the journal ACS Nano, Science Alert reports.
It is noted that the developed patch helps in the transformation of white fat into brown. White fat stores excess energy in large drops of triglycerides, while, like brown fat, they are much less and it contains more mitochondria that burn fat. A similar effect is achieved with the use of hormones, however, they act on the entire body and have side effects.
The researchers tested the effect of rosiglitazone, a fat-breaking drug, embedded in nanoparticles on a one-square-centimeter patch. With the help of microneedles, it is attached to the skin, after which they decompose and release the drug. In trials on obese mice, scientists glued two patches to them: one containing the drug, and the other empty. The patches were renewed every three days and repeated for four weeks. All this time, experts monitored the weight, appetite, physical activity and metabolism of the animals.
As a result, the scientists observed a 20 percent reduction in fat in the part of the body where the patch with the drug was attached. At the same time, the number of white fat cells decreased and brown fat cells appeared. Also, the mice have decreased blood glucose levels. Experts believe that this method may soon be approved for testing in humans.