Dryness and discomfort in the nose can be the very first signs of coronavirus. These symptoms occur in those infected even before the disappearance of smell and taste, according to Spanish scientists, reports "Moscow 24". Coronavirus, penetrating the body, affects the epithelium of the nasopharynx. The spike protein of the SARS-CoV-2 virus is inserted into the epithelial ACE2 receptor in order to begin replication in healthy cells. This causes a loss of smell and taste in 80 percent of infections. The epithelium of the respiratory and intestinal tracts contains goblet cells that secrete special mucus to protect the respiratory tract from viruses. According to scientists, SARS-CoV-2 infects them, and the goblet cells stop secreting this mucus. Researchers from the University of Barcelona have organized trials in a group of 35 people with mild coronavirus and a loss of smell, and in a group of healthy people. The age and sex of the participants in both groups were the same.